| 2021-08-28 15:00:1028. August 2021 |   BLK Slavia Praha vs GISA LIONS (ohne Zuschauer) | 44 - 69 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | | Testspiel |
| 2021-09-04 17:30:314. September 2021 |  GISA LIONS vs Rheinland Lions | 51 - 63 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | Vorbereitungsturnier |
| 2021-09-05 10:00:495. September 2021 |  GISA LIONS vs TK Hannover | 60 - 71 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | Vorbereitungsturnier |
| 2021-09-08 19:00:598. September 2021 |  Veilchen Ladies vs GISA LIONS (ohne Zuschauer) | 77 - 56 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Felix Klein Gymnasium I (FKG I) | Testspiel |
| 2021-09-26 16:00:4326. September 2021 | Rheinland Lions vs GISA LIONS | 16:00:4316:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | WEKITA SPORTARENA | 1. Spieltag |
| 2021-10-01 19:00:071. Oktober 2021 | medical instinct Veilchen vs GISA LIONS | 19:00:0719:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Felix Klein Gymnasium I (FKG I) | 2. Spieltag |
| 2021-10-03 16:00:383. Oktober 2021 | GISA LIONS vs TK Hannover | 16:00:3816:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 3. Spieltag |
| 2021-10-09 19:00:429. Oktober 2021 |  Eisvoegel vs GISA LIONS | 19:00:4219:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Sepp-Glaser-Halle | 4. Spieltag |
| 2021-10-14 18:00:5214. Oktober 2021 | GISA LIONS vs medical instinct Veilchen | 18:00:5218:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 2. Runde DBBL-Pokal |
| 2021-10-17 16:00:3117. Oktober 2021 |  GISA LIONS vs BC Marburg | 16:00:3116:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 5. Spieltag |
| 2021-10-24 16:00:2524. Oktober 2021 |  GISA LIONS vs Capitol Bascats | 16:00:2516:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 6. Spieltag |
| 2021-10-31 15:00:0931. Oktober 2021 |  Royals vs GISA LIONS | 15:00:0915:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Hermann-Neuberger-Halle | 7. Spieltag |
| 2021-11-06 18:00:586. November 2021 |  GISA LIONS vs Eigner Angels | 18:00:5818:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 8. Spieltag |
| 2021-11-20 18:00:1120. November 2021 |  Herne vs GISA LIONS | 18:00:1118:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | H2K-Arena | 9. Spieltag |
| 2021-11-27 18:00:4127. November 2021 |  GISA LIONS vs TSV 1880 | 18:00:4118:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 10. Spieltag |
| 2021-12-05 16:00:405. Dezember 2021 |  Panthers vs GISA LIONS | 16:00:4016:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | OSC Halle A | 11. Spieltag |
| 2021-12-11 18:00:4211. Dezember 2021 |  GISA LIONS vs Rutronik Stars | 18:00:4218:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 12. Spieltag |
| 2021-12-18 17:30:2918. Dezember 2021 |  USC Heidelberg vs GISA LIONS | 17:30:2917:30 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | ISSW 700 Heidelberg | 13. Spieltag |
| 2021-12-22 19:30:2222. Dezember 2021 | GISA LIONS vs medical instinct Veilchen | 19:30:2219:30 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 14. Spieltag |
| 2021-12-29 19:00:3829. Dezember 2021 | BC Marburg vs GISA LIONS | 19:00:3819:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Großsporthalle KSM Marburg | 15. Spieltag |
| 2022-01-02 16:00:362. Januar 2022 | GISA LIONS vs Royals | 16:00:3616:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 16. Spieltag |
| 2022-01-09 16:00:539. Januar 2022 | Eigner Angels vs GISA LIONS | 16:00:5316:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Herrmann-Kesser-Halle | 17. Spieltag |
| 2022-01-15 18:00:5215. Januar 2022 | GISA LIONS vs Herne | 18:00:5218:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 18. Spieltag |
| 2022-01-23 16:00:5323. Januar 2022 | TK Hannover vs GISA LIONS | 16:00:5316:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Sporthalle Birkenstraße | 19. Spieltag |
| 2022-01-29 18:00:4329. Januar 2022 | GISA LIONS vs Rheinland Lions | 18:00:4318:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 20. Spieltag |
| 2022-02-05 19:00:425. Februar 2022 | Rutronik Stars vs GISA LIONS | 19:00:4219:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | Schulzentrum Dietlingen | 21. Spieltag |
| 2022-02-12 18:00:0612. Februar 2022 | GISA LIONS vs USC Heidelberg | 18:00:0618:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 22. Spieltag |
| 2022-02-19 14:00:5619. Februar 2022 | Capitol Bascats vs GISA LIONS | 14:00:5614:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SCHULZENTRUM HERKENRATH | 23. Spieltag |
| 2022-02-27 16:00:4227. Februar 2022 | GISA LIONS vs Eisvoegel | 16:00:4216:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 24. Spieltag |
| 2022-03-06 16:00:546. März 2022 | TSV 1880 vs GISA LIONS | 16:00:5416:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | BADRIA Sport & Freizeitzentrum | 25. Spieltag |
| 2022-03-13 16:00:3713. März 2022 | GISA LIONS vs Panthers | 16:00:3716:00 | Toyota 1. Damen Basketball Bundesliga | 2021/22 | SWH.arena | 26. Spieltag |
